Description:
- The goal of this initiative is to stimulate basic research on the role of glial cells in pain disorders of the orofacial complex and in particular, studies on the interactions between glial cells and neurons that lead to pathological pain states. This initiative will encourage molecular, cellular, and animal studies on 1) the mechanisms by which stimulation of primary afferent nociceptors (neurons) lead to activation of spinal cord, brain, and peripheral glial cells; 2) the influence of activated glial cells (astrocytes and microglia) on nociceptive neuron function in experimental pain models; 3) the identification of glial cell proteins and signaling pathways important in maintaining chronic pain states; 4) the identification of the neuronal proteins and signaling systems regulated by activated glial cells; and 5) the role of activated microglia as antigen presenting cells influencing systemic immune cell interactions with the CNS. The knowledge gai!
ned from these approaches will lead to rapid and new advances in the identification analgesic targets for chronic pain disorders.
- The total amount to be awarded is $2,000,000.
- The anticipated number of awards is eight (8) to ten (10).
- The types of mechanisms will include R01 and R21 grants.
- Eligible organizations include:
- For-profit organizations
- Non-profit organizations
- Public or private institutions, such as universities, colleges, hospitals, and laboratories
- Units of State government
- Units of local government
- Eligible agencies of the Federal government
- Foreign Institutions
- Domestic Institutions
- Faith-based or community-based organizations
- Applicants may submit more than one application, provided they are scientifically distinct.
- See Section IV.1 for application materials.
- Telecommunications for the hearing impaired is available at: TTY 301-451-0088
Who can apply:
Anyone/General Public
City Or Township Governments
County Governments
Federally Recognized Indian Tribal Governments
Independent School Districts
Individual/Family
Minority Group
Native American Organization
Non-Government - General
Nonprofits Having A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Nonprofits That Do Not Have A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Other Private Institution/Organization
Private Institutions Of Higher Education
Private Nonprofit Institution/Organization (Includes Institutions Of Higher Education, Hospitals)
Profit Organization
Public And State Controlled Institutions Of Higher Education
Public Housing Authorities/Indian Housing Authorities
Quasi-Public Nonprofit Institution/Organization
Small Business (Less Than 500 Employees
Special District Governments
State (Includes District Of Columbia; Includes Institutions Of Higher Education And Hospitals)
U.S. Territories And Possessions (Includes Institutions Of Higher Education, Hospitals)
Eligible functional categories:
Funding Sources:
Oral Diseases and Disorders Research
More Information:
http://grants.nih.gov/grants/guide/rfa-files/RFA-DE-06-005.html
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NIH OER Webmaster
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